Role of the IFN-induced helicase IFIH1 in type 1 diabetes

IFN 诱导的解旋酶 IFIH1 在 1 型糖尿病中的作用

• 批准号: nhmrc : 491094
• 负责人: Prof Bryan Williams
• 金额: $ 42.05万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ifn-induced-1-diabetes/77572
• 关键词: Role; IFN; induced; helicase; IFIH1

Type 1 diabetes (T1D) is presently the most common chronic disease of childhood and is increasing, with incidence in children under five doubling over the last five years. Recent findings indicate the ifih1 gene is important in T1D. Our research aims to establish the contribution of this gene to the disease. It is hoped that recognition of relevant pathological molecules will allow identification of risk factors for disease development and, ultimately, targets for therapeutic intervention.

1型糖尿病（T1D）目前是儿童最常见的慢性疾病，并且正在增加，在过去五年中，五岁以下儿童的发病率翻了一番。最近的研究结果表明ifih1基因在T1D中很重要。我们的研究旨在确定这种基因对这种疾病的贡献。人们希望，识别相关的病理分子将允许识别疾病发展的风险因素，并最终确定治疗干预的目标。