Functional analysis of relapse predictive genes in Wilms tumour

肾母细胞瘤复发预测基因的功能分析

• 批准号: nhmrc : 491092
• 负责人: Prof Bryan Williams
• 金额: $ 38.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-analysis-relapse-wilms-tumour/81040
• 关键词: Functional; analysis; relapse; predictive; genes

Wilms tumor is a paediatric kidney cancer, the most common abdominal tumour seen in children. About 20% of Wilms tumour patients have relapsing fatal tumours. We have found two genes that mark tumours which relapse: C-EBPB and CLK1. Characterization of C-EBPB and CLK1 will yield new information regarding the mechanisms underlying development and progression of Wilms tumours, leading to improved treatment for Wilms tumor patients. Both C-EBPB and CLK1 may also have roles in other human cancers.

肾母细胞瘤是一种儿科肾癌，是儿童最常见的腹部肿瘤。大约20%的肾母细胞瘤患者患有复发性致命肿瘤。我们发现了两个标记肿瘤复发的基因：C-EBPB和CLK 1。C-EBPB和CLK 1的表征将产生关于肾母细胞瘤发展和进展的潜在机制的新信息，从而改善肾母细胞瘤患者的治疗。C-EBPB和CLK 1也可能在其他人类癌症中发挥作用。