The role of IL21 in integrating proliferation, migration and differentiation following B cell activation.

免疫力对健康至关重要，需要产生抗体。最好的抗体是由来自专门结构的B细胞产生的，称为生发中心（GC）。为了理解为什么有时免疫力很好-儿童疫苗-而其他时候不是-艾滋病毒感染，老年人-我们需要了解GC内部发生了什么。我们的预测是，通过了解GC B细胞的行为，我们将从不良的免疫反应中分辨出良好的免疫反应，从而改善免疫反应。

Immunity is essential to health and requires the production of antibodies. The best antibodies are made by B-cells coming from specialised structures, called germinal centres (GC). To understand why sometimes immunity is excellent - childhood vaccines - and other times not - HIV infection, aged people - we need to understand what happens inside GC. Our prediction is that by understanding GC B cell behaviour, we will resolve good from poor immune responses and thereby develop improvements.