The role of immune cells and the transcription factor Hmga1 in boosting neural regeneration

免疫细胞和转录因子 Hmga1 在促进神经再生中的作用

• 批准号: nhmrc : 1068411
• 负责人: Dr Jan Kaslin
• 金额: $ 25.04万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-immune-cells-neural-regeneration/455345
• 关键词: role; immune; cells; transcription; factor

Brain trauma and neuro degenerative diseases are prevalent conditions that cause life-long impact and severe disability. Currently there are no therapeutical options available and the prognosis for recovery is very poor. We recently determined the crucial and beneficial role of inflammation in neural regeneration. The inflammatory signals that initiate regeneration are not known. This proposal seeks to identify signals and gene programs that regulate the inflammation induced regeneration response.

脑外伤和神经退行性疾病是导致终身影响和严重残疾的普遍状况。目前尚无治疗选择，恢复的预后非常差。我们最近确定了炎症在神经再生中的关键和有益作用。启动再生的炎症信号尚不清楚。该提案旨在确定调节炎症引起的再生反应的信号和基因程序。