The Role of LIM Domain Kinase 1 in the Pathogenesis of Alzheimer’s Disease

LIM 结构域激酶 1 在阿尔茨海默病发病机制中的作用

• 批准号: nhmrc : 1143848
• 负责人: Dr Yazi Ke
• 金额: $ 38.24万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-lim-domain-alzheimers-disease/1320043
• 关键词: Role; LIM; Domain; Kinase; Pathogenesis

Alzheimer’s disease is characterized by progressive loss of cognition. Few Australians have remained untouched by the effects of Alzheimer’s disease in their families or social circles. Unfortunately, there is no cure and current therapies are limited to modest symptomatic relief. This project will explore the role of a protein that regulates the structural integrity of brain cells in disease, and test if targeting this protein could prevent disease progression.

阿尔茨海默氏病的特征是认知的进行性丧失。很少有澳大利亚人在家庭或社交圈中不受阿尔茨海默病的影响。不幸的是，没有治愈方法，目前的治疗仅限于适度的症状缓解。该项目将探索一种调节疾病中脑细胞结构完整性的蛋白质的作用，并测试靶向这种蛋白质是否可以预防疾病进展。