Interaction of amyloid-beta and tau pathology in Alzheimer's disease

阿尔茨海默病中 β 淀粉样蛋白和 tau 蛋白病理学的相互作用

• 批准号: nhmrc : 1016785
• 负责人: Dr Yazi Ke
• 金额: $ 8.17万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interaction-amyloid-beta-alzheimers-disease/109808
• 关键词: Interaction; amyloid; beta; tau; pathology

Currently, over 200,000 Australians are affected by Alzheimer's disease (AD) and related forms of dementia, causing a huge socio-economic damage. To overcome the lack of effective treatments, we need to understand the underlying causes and translate them into therapy. Using state-of-the-art cell culture and genetic mouse models, I will reveal fundamental processes in AD and related dementias, and develop tailored treatments to battle these devastating disorders.

目前，超过 20 万澳大利亚人患有阿尔茨海默病 (AD) 和相关形式的痴呆症，造成了巨大的社会经济损失。为了克服缺乏有效治疗的问题，我们需要了解根本原因并将其转化为治疗方法。我将利用最先进的细胞培养和基因小鼠模型，揭示 AD 和相关痴呆症的基本过程，并开发定制的治疗方法来对抗这些破坏性疾病。