The role of MBOAT7 in hepatic inflammation: implications for therapy

MBOAT7 在肝脏炎症中的作用：对治疗的影响

• 批准号: nhmrc : 1145766
• 负责人: A/Pr Leon Adams
• 金额: $ 57.36万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-mboat7-hepatic-implications-therapy/1320514
• 关键词: role; MBOAT7; hepatic; inflammation; implications

When a fatty liver progresses to develop inflammation, patients are at-risk of liver-related morbidity and death. Currently, there are no effective therapies. From human studies, we have discovered that a lipid modifying enzyme (MBOAT7) profoundly regulates liver inflammation. In this proposal, we will obtain a detailed understanding of how the activity of this pathway modulates inflammation. We expect to show that MBOAT7 is a novel ‘druggable’ pathway for the treatment of liver inflammation.

当脂肪肝进展为炎症时，患者有肝脏相关发病和死亡的风险。目前还没有有效的治疗方法。从人类研究中，我们发现脂质修饰酶（MBOAT 7）深刻地调节肝脏炎症。在这个提议中，我们将详细了解这种途径的活性如何调节炎症。我们希望证明MBOAT7是一种治疗肝脏炎症的新的“可药物化”途径。