Therapeutic regulation of hepatic steatosis and lipid transport in the metabolic syndrome

代谢综合征中肝脂肪变性和脂质转运的治疗调节

• 批准号: nhmrc : 572585
• 负责人: A/Pr Leon Adams
• 金额: $ 34.84万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/therapeutic-regulation-hepatic-metabolic-syndrome/97057
• 关键词: Therapeutic; regulation; hepatic; steatosis; lipid

Obesity is an increasing problem in Australia. Elevated fat levels in the liver and blood are associated with obesity and increased risk for heart disease. In this project, we will demostrate new mechanisms of action of Pioglitazone (an insulin-sensitizing agent) and Omacor (fish oils) that will complement the favourable efect of weight loss in the treatment of elevated blood fats and reduction in risk of heart disease in an important groups of subject in the population.

肥胖在澳大利亚是一个日益严重的问题。肝脏和血液中的脂肪水平升高与肥胖和心脏病风险增加有关。在这个项目中，我们将展示吡格列酮（一种胰岛素增敏剂）和Omacor（鱼油）的新的作用机制，这将补充减肥在治疗血脂升高和降低心脏病风险方面的有利作用。