The role of microRNAs in the regulation of antiviral and inflammatory responses during experimental rhinovirus infection

microRNA在实验性鼻病毒感染过程中抗病毒和炎症反应调节中的作用

• 批准号: nhmrc : 631075
• 负责人: Prof Joerg Mattes
• 金额: $ 40.35万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-micrornas-regulation-rhinovirus-infection/77604
• 关键词: role; microRNAs; regulation; antiviral; inflammatory

Asthma exacerbations due to viral infections are a major health and economic burden to our society. Treatment of asthma exacerbations focuses on reducing the symptoms rather than the cause of the disease. Virus-induced asthma exacerbation are widely thought to be due to an abnormal influx of white blood cells into the lungs (inflammation) and an altered anti-viral responses. In this project we will explore novel strategies to inhibit inflammation and to promote the anti-viral response.

由于病毒感染引起的哮喘恶化是我们社会的主要健康和经济负担。哮喘急性发作的治疗重点是减少症状，而不是疾病的原因。病毒引起的哮喘恶化被广泛认为是由于白色血细胞异常流入肺部（炎症）和抗病毒反应的改变。在这个项目中，我们将探索新的策略来抑制炎症和促进抗病毒反应。