Mechanisms and treatment of early life chlamydial infection and associated asthma

生命早期衣原体感染及相关哮喘的机制和治疗

• 批准号: nhmrc : 569219
• 负责人: Prof Joerg Mattes
• 金额: $ 41.09万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-treatment-early-associated-asthma/96658
• 关键词: Mechanisms; treatment; early; life; chlamydial

Asthma is a serious respiratory disease that results from certain immune responses to allergens and there are no cures. Immune responses and lung structure may be permanently altered by respiratory chlamydial infection early in life that leads to reduced lung function and asthma but how this occurs is unknown. In this project we will determine how early life infections affect immune responses, lung function and asthma and test novel treatments and preventions for infection-associated asthma.

哮喘是一种严重的呼吸道疾病，由对过敏原的某些免疫反应引起，目前尚无治愈方法。免疫反应和肺结构可能会因生命早期的呼吸道衣原体感染而永久改变，导致肺功能降低和哮喘，但这是如何发生的尚不清楚。在这个项目中，我们将确定生命早期感染如何影响免疫反应，肺功能和哮喘，并测试感染相关哮喘的新治疗和预防方法。