The role of mucosal-associated invariant T (MAIT) cells and gut micro-biota in the pathogenesis of paediatric autoimmune liver disease (AILD).

粘膜相关不变 T (MAIT) 细胞和肠道微生物群在儿童自身免疫性肝病 (AILD) 发病机制中的作用。

• 批准号: nhmrc : 1133563
• 金额: $ 8.53万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-mucosal-associated-disease-aild/948856
• 关键词: role; mucosal; associated; invariant; MAIT

Liver disease can develop when a faulty immune system attacks the liver, occasionally leading to significant liver scarring and liver transplantation. Children who develop this condition need life-long treatment, but not every child responds. I intend to study immune cells and their activity in the blood and liver of affected children. By identifying the role of the immune system in liver inflammation, we hope to find out why children develop this disease and how best to treat them.

当免疫系统缺陷攻击肝脏时，可能会发生肝脏疾病，偶尔会导致严重的肝脏瘢痕和肝移植。患有这种疾病的儿童需要终身治疗，但不是每个孩子都有反应。我打算研究受影响儿童血液和肝脏中的免疫细胞及其活动。通过确定免疫系统在肝脏炎症中的作用，我们希望找出儿童患上这种疾病的原因以及如何最好地治疗他们。