The role of necroptosis in development, the immune system and autoimmune pathology

坏死性凋亡在发育、免疫系统和自身免疫病理学中的作用

• 批准号: nhmrc : 1046010
• 负责人: Prof Andreas Strasser
• 金额: $ 30.28万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-necroptosis-development-autoimmune-pathology/111809
• 关键词: role; necroptosis; development; immune; system

Programmed cell death plays critical roles in development and cell-turnover in the adult. Defects in this process can cause cancer or autoimmune diseases. We will use genetic and biochemical approaches to define the individual roles of necroptosis, a newly described cell death process, and those overlapping with apoptosis in normal development and cell-turnover as well as in cancer and autoimmune diseases. The objective of this work is to identify potential targets for therapeutic intervention in cancer or immunopathology.

程序性细胞死亡在成体的发育和细胞更新中起着关键作用。这个过程中的缺陷可能导致癌症或自身免疫性疾病。我们将使用遗传和生物化学方法来定义坏死性凋亡的个体作用，这是一种新描述的细胞死亡过程，以及在正常发育和细胞周转以及癌症和自身免疫性疾病中与凋亡重叠的过程。这项工作的目的是确定癌症或免疫病理学治疗干预的潜在靶点。