Learning the mechanisms of programmed cell death and tumour suppression to develop novel cancer therapies

了解程序性细胞死亡和肿瘤抑制的机制，以开发新的癌症疗法

• 批准号: nhmrc : GNT1116937
• 负责人: Prof Andreas Strasser
• 金额: $ 86.39万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/learning-mechanisms-programmed-cancer-therapies/1346998
• 关键词: Learning; mechanisms; programmed; cell; death

Our bodies prevent the development of cancer through tumour suppressive processes, which also affect the outcome of cancer therapy. Programmed cell death (apoptosis) is one such process, and defects in apoptosis promote cancer development and impair the response of tumour cells to anti-cancer therapies. My laboratory uses molecular biology and cell biology approaches to investigate the mechanisms of cell death and tumour suppression, partnering with pharma to develop novel cancer therapies.

我们的身体通过抑制肿瘤的过程来防止癌症的发展，这也影响了癌症治疗的结果。细胞程序性死亡就是其中的一个过程，而细胞凋亡的缺陷促进了肿瘤的发展，损害了肿瘤细胞对抗癌治疗的反应。我的实验室使用分子生物学和细胞生物学的方法来研究细胞死亡和肿瘤抑制的机制，并与制药公司合作开发新的癌症疗法。