The Role of Neuronal Nicotinic Receptor Subunits in the Self-Administration and Relapse to Alcohol Seeking:Treatments for Alcohol Dependence

神经元烟碱受体亚基在自我管理和酗酒复发中的作用：酒精依赖的治疗

• 批准号: nhmrc : 1049427
• 负责人: Prof Selena Bartlett
• 金额: $ 35.46万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-neuronal-nicotinic-alcohol-dependence/112082
• 关键词: Role; Neuronal; Nicotinic; Receptor; Subunits

The World Health Organization reports that alcohol causes almost two million deaths every year and results in physical disability or shortened life span for at least 58 million others. Despite the fact that addiction represents more than 40% of brain-related illnesses, there is a dearth of innovative treatments. The overall goal of my research is to develop more effective medications for the treatment of alcohol use disorder by targeting the neuronal nicotinic receptor subtypes that have been specifically altered by heavy alcohol intake.

世界卫生组织报告说，酒精每年造成近200万人死亡，至少5800万人身体残疾或寿命缩短。尽管成瘾占大脑相关疾病的40%以上，但缺乏创新的治疗方法。我的研究的总体目标是通过靶向神经元烟碱受体亚型来开发更有效的药物来治疗酒精使用障碍，这些亚型已经被大量饮酒所特异性改变。