Sex and speciation: molecular evolution of sexual dimorphism and mechanisms of speciation
性别与物种形成:性二态性的分子进化和物种形成机制
基本信息
- 批准号:235-2007
- 负责人:
- 金额:$ 4.91万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2008
- 资助国家:加拿大
- 起止时间:2008-01-01 至 2009-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
For many decades, the problem of speciation has been refractory to detailed genetic analyses, however with the availability of an increasing number of sequenced genomes, expression data and transgenic methodology, the scientific community is now in a position to understand the origins and evolution of species. During the last tenure of our NSERC grant, our studies were specifically directed towards understanding molecular evolution of sex- and reproduction-related genes and their role in speciation. We showed that genes involved in reproduction are evolving faster than genes with other functions, and that sexual function (male-/female-biased) and chromosomal location (sex vs. non-sex) are major factors influencing rapid gene evolution. Our goal in the next phase is to use modern molecular methodology to to test the hypothesis that variation and evolution of sexual system genes through their effects on sexual dimorphism are responsible for the development of reproductive isolation and speciation. Large scale gene expression studies of sterile interspecific hybrids have highlighted the importance of regulatory sequences in controlling gene expression and their role in speciation. We will analyse the evolution of cis-regularory sequences involved in sex-, tissue- and developmental stage-specific functions. Transgenics, using coding an regulatory sequences of different species for selected candidate genes will be done. Finally, with a view to link molecules to morphology and to unravel the dynamics of natural and sexual selection for a sexual a trait, we have undertaken a comprehensive study of the evolution of the male sexual trait, the sex combs, in Drosophila species. Studies involving artificial selection, behavioural experiments and gene expression profiles of selected lines will provide an understanding of the evolutionary dynamics of this sexual trait which has evolved rapidly and independently in different groups of Drosophila species. The results will shed light on the origins of species as well as on the evolution of sexual system genes and the tempo of change during speciation.
几十年来,物种形成的问题一直难以进行详细的遗传分析,但随着越来越多的基因组测序,表达数据和转基因方法的可用性,科学界现在能够了解物种的起源和进化。在我们的NSERC赠款的最后任期内,我们的研究是专门针对了解性和生殖相关基因的分子进化及其在物种形成中的作用。我们发现,参与生殖的基因比具有其他功能的基因进化得更快,性功能(男性/女性偏见)和染色体位置(性别与非性别)是影响快速基因进化的主要因素。我们下一阶段的目标是利用现代分子生物学方法来验证性系统基因的变异和进化通过其对性二型性的影响对生殖隔离和物种形成的发展负责的假设。大规模的不育种间杂种的基因表达研究强调了调控序列在控制基因表达和物种形成中的作用的重要性。我们将分析参与性别,组织和发育阶段特异性功能的顺式调节序列的演变。转基因,使用不同物种的编码调控序列为选定的候选基因将被完成。最后,为了将分子与形态学联系起来,并揭示性特征的自然选择和性选择的动力学,我们对果蝇属物种的雄性性特征(性梳)的进化进行了全面的研究。涉及人工选择、行为实验和选定系的基因表达谱的研究将提供对这种性特征进化动态的了解,这种性特征在果蝇物种的不同群体中迅速且独立地进化。这些结果将有助于阐明物种的起源,以及性系统基因的进化和物种形成过程中的变化克里思。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Singh, Rama其他文献
Sex and speciation: Drosophila reproductive tract proteins- twenty five years later.
- DOI:
10.1155/2012/191495 - 发表时间:
2012-01-01 - 期刊:
- 影响因子:0
- 作者:
Singh, Rama;Jagadeeshan, Santosh - 通讯作者:
Jagadeeshan, Santosh
Singh, Rama的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Singh, Rama', 18)}}的其他基金
Molecular evolution of sex and reproduction related genes and their role in speciation: The genomic architecture of hybrid male sterility
性和生殖相关基因的分子进化及其在物种形成中的作用:杂种雄性不育的基因组结构
- 批准号:
235-2013 - 财政年份:2017
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Molecular evolution of sex and reproduction related genes and their role in speciation: The genomic architecture of hybrid male sterility
性和生殖相关基因的分子进化及其在物种形成中的作用:杂种雄性不育的基因组结构
- 批准号:
235-2013 - 财政年份:2016
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Molecular evolution of sex and reproduction related genes and their role in speciation: The genomic architecture of hybrid male sterility
性和生殖相关基因的分子进化及其在物种形成中的作用:杂种雄性不育的基因组结构
- 批准号:
235-2013 - 财政年份:2015
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Molecular evolution of sex and reproduction related genes and their role in speciation: The genomic architecture of hybrid male sterility
性和生殖相关基因的分子进化及其在物种形成中的作用:杂种雄性不育的基因组结构
- 批准号:
235-2013 - 财政年份:2014
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Molecular evolution of sex and reproduction related genes and their role in speciation: The genomic architecture of hybrid male sterility
性和生殖相关基因的分子进化及其在物种形成中的作用:杂种雄性不育的基因组结构
- 批准号:
235-2013 - 财政年份:2013
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Molecular evolution of sexual systems genes and their role in speciation
性系统基因的分子进化及其在物种形成中的作用
- 批准号:
407053-2012 - 财政年份:2012
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Sex and speciation: molecular evolution of sexual dimorphism and mechanisms of speciation
性别与物种形成:性二态性的分子进化和物种形成机制
- 批准号:
235-2007 - 财政年份:2011
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Sex and speciation: molecular evolution of sexual dimorphism and mechanisms of speciation
性别与物种形成:性二态性的分子进化和物种形成机制
- 批准号:
235-2007 - 财政年份:2010
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Sex and speciation: molecular evolution of sexual dimorphism and mechanisms of speciation
性别与物种形成:性二态性的分子进化和物种形成机制
- 批准号:
235-2007 - 财政年份:2009
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Sex and speciation: molecular evolution of sexual dimorphism and mechanisms of speciation
性别与物种形成:性二态性的分子进化和物种形成机制
- 批准号:
235-2007 - 财政年份:2007
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
水溶液平衡化学模型及其水文地球化学应用研究
- 批准号:40372114
- 批准年份:2003
- 资助金额:33.0 万元
- 项目类别:面上项目
相似海外基金
Molecular evolution of sex and reproduction related genes and their role in speciation: The genomic architecture of hybrid male sterility
性和生殖相关基因的分子进化及其在物种形成中的作用:杂种雄性不育的基因组结构
- 批准号:
235-2013 - 财政年份:2017
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Investigating the special role of sex chromosomes in speciation: discovering the molecular identities, functions, and evolutionary histories of X-linked hybrid male sterility genes in Drosophila
研究性染色体在物种形成中的特殊作用:发现果蝇X连锁杂种雄性不育基因的分子身份、功能和进化历史
- 批准号:
9751085 - 财政年份:2017
- 资助金额:
$ 4.91万 - 项目类别:
Investigating the special role of sex chromosomes in speciation: discovering the molecular identities, functions, and evolutionary histories of X-linked hybrid male sterility genes in Drosophila
研究性染色体在物种形成中的特殊作用:发现果蝇X连锁杂种雄性不育基因的分子身份、功能和进化历史
- 批准号:
9447747 - 财政年份:2017
- 资助金额:
$ 4.91万 - 项目类别:
Molecular evolution of sex and reproduction related genes and their role in speciation: The genomic architecture of hybrid male sterility
性和生殖相关基因的分子进化及其在物种形成中的作用:杂种雄性不育的基因组结构
- 批准号:
235-2013 - 财政年份:2016
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Molecular evolution of sex and reproduction related genes and their role in speciation: The genomic architecture of hybrid male sterility
性和生殖相关基因的分子进化及其在物种形成中的作用:杂种雄性不育的基因组结构
- 批准号:
235-2013 - 财政年份:2015
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Molecular evolution of sex and reproduction related genes and their role in speciation: The genomic architecture of hybrid male sterility
性和生殖相关基因的分子进化及其在物种形成中的作用:杂种雄性不育的基因组结构
- 批准号:
235-2013 - 财政年份:2014
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Molecular evolution of sex and reproduction related genes and their role in speciation: The genomic architecture of hybrid male sterility
性和生殖相关基因的分子进化及其在物种形成中的作用:杂种雄性不育的基因组结构
- 批准号:
235-2013 - 财政年份:2013
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Sex and speciation: molecular evolution of sexual dimorphism and mechanisms of speciation
性别与物种形成:性二态性的分子进化和物种形成机制
- 批准号:
235-2007 - 财政年份:2011
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Sex and speciation: molecular evolution of sexual dimorphism and mechanisms of speciation
性别与物种形成:性二态性的分子进化和物种形成机制
- 批准号:
235-2007 - 财政年份:2010
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual
Sex and speciation: molecular evolution of sexual dimorphism and mechanisms of speciation
性别与物种形成:性二态性的分子进化和物种形成机制
- 批准号:
235-2007 - 财政年份:2009
- 资助金额:
$ 4.91万 - 项目类别:
Discovery Grants Program - Individual