The role of the orbitofrontal cortex in disorders of response inhibition

眶额皮质在反应抑制疾病中的作用

• 批准号: nhmrc : GNT1148244
• 负责人: Dr Laura Bradfield
• 金额: $ 50.84万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-orbitofrontal-cortex-response-inhibition/1348872
• 关键词: role; orbitofrontal; cortex; disorders; response

We will investigate the role of the orbitofrontal cortex (OFC) in decision-making, particularly the effect of hyperactivity in the medial vs. ventrolateral orbitofrontal cortex on decision-making. Hyperactivity in these structures has been linked to obsessive compulsive disorder and, in line with the distinct functions of the different regions of OFC, we develop and test a novel hypothesis as to the psychological and neural bases of the obsessions and compulsions distinctive to that disorder.

我们将研究眶额皮质（OFC）在决策中的作用，特别是内侧与腹外侧眶额皮质的过度活跃对决策的影响。这些结构中的过度活跃与强迫症有关，并且与OFC不同区域的不同功能一致，我们开发并测试了一种新的假设，即这种障碍所特有的强迫和强迫的心理和神经基础。