Dementia related deficits in striatal cholinergic function and decision-making

痴呆相关纹状体胆碱能功能和决策缺陷

• 批准号: nhmrc : GNT1087689
• 负责人: Dr Laura Bradfield
• 金额: $ 26.77万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dementia-related-deficits-decision-making/1345707
• 关键词: Dementia; related; deficits; striatal; cholinergic

This proposal will provide essential new information on the role of deficits in decision-making associated with Parkinson’s disease dementia. We will use an innovative animal model to assess the influence of neurodegeneration and neuroinflammation the consequent loss of function in the neuronal systems supporting the learning and memory processes that contribute to goal-directed action, particularly the way new learning interacts with existing memory to guide choice and decision-making.

该提案将提供有关帕金森病痴呆症相关决策中缺陷作用的重要新信息。我们将使用一种创新的动物模型来评估神经退行性变和神经炎症的影响，即神经系统功能的丧失，这些神经系统支持有助于目标导向行动的学习和记忆过程，特别是新的学习与现有记忆相互作用的方式，以指导选择和决策。