The role of peroxisome proliferator activated receptor gamma in sodium transport in human proximal tubule cells

过氧化物酶体增殖物激活受体γ在人近曲小管细胞钠转运中的作用

• 批准号: nhmrc : 457561
• 负责人: Dr Sonia Saad
• 金额: $ 37.8万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-peroxisome-proliferator-tubule-cells/78366
• 关键词: role; peroxisome; proliferator; activated; receptor

Renal failure accounts for a considerable component of the excess morbidity and mortality observed in patients with diabetes mellitus. In addition, the emotional, social and cost to the community of dialysis is enormous. PPARgamma is activated by drugs that have been recently introduced for the treatment of type 2 diabetes mellitus. The propensity for these drugs to cause fluid retention has emerged recently as the most common serious adverse drug reaction associated with these compounds. the definitive cause of fluid retention with the use of PPAR gamma agonists is not known. Studies reported in the last 12 - 18 months have suggested that a common pathway may be involved in the development of the fluid retention, the high blood pressure and the scarring that occurs in the kidney. This project will be the first to provide a comprehensive examination of the effect of PPARgamma induction on renal sodium absorption and fluid retention in the human proximal tubule cells and the potential molecular mechanisms underlying them. This will provide insight as to potential adjuvant treatments for patients with diabetes.

肾功能衰竭占糖尿病患者中观察到的过度发病率和死亡率的相当大的组成部分。此外，透析社区的情感、社会和成本也是巨大的。PPARgamma被最近引入用于治疗2型糖尿病的药物激活。这些药物引起液体潴留的倾向最近已成为与这些化合物相关的最常见的严重药物不良反应。使用过氧化物酶体增殖物激活受体γ激动剂引起液体潴留的确切原因尚不清楚。过去12 - 18个月的研究报告表明，一个共同的途径可能涉及液体潴留，高血压和肾脏中发生的疤痕的发展。该项目将是第一个全面研究PPARgamma诱导对人近端小管细胞肾钠吸收和液体潴留的影响及其潜在的分子机制。这将为糖尿病患者的潜在辅助治疗提供见解。