Dietary supplementation in animal models of neurodevelopmental disorders

神经发育障碍动物模型中的膳食补充剂

基本信息

  • 批准号:
    7617-2006
  • 负责人:
  • 金额:
    $ 3.22万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2008
  • 资助国家:
    加拿大
  • 起止时间:
    2008-01-01 至 2009-12-31
  • 项目状态:
    已结题

项目摘要

The behavioural problems associated with Fetal Alcohol Syndrome (FAS) and Attention Deficit Hyperactivity disorder (ADHD) in humans include difficulties with learning and memory. We use animal models to understand the biological mechanisms underlying these conditions, addressing whether specific dietary supplements may prove useful as preventive and/or rehabilitative interventions.We have shown that if young rats are exposed to ethanol during the time when their brain is growing most rapidly, they will show impairments in short-term memory that are related to changes in gene-expression in the hippocampus, a brain region associated with memory storage. An increase in the amount of choline in the diet of young rats has been shown to result in memory enhancement and an increase in growth factors in the hippocampus. Thus we propose to examine whether such dietary treatment will have beneficial effects on memory proceses in ethanol-exposed rats. To this end we will feed young rats amounts of ethanol equivalent to those consumed by heavy "binge-drinking" pregnant women and at the same time supplement their diets with choline. We expect that these rats will show better short-term memory for the location of a hidden escape platform in a water-maze than rats fed ethanol, but not choline; we also expect that the dietary treatment will  reverse the changes seen in their brains.We are also in the process of completing a series of studies on learning and memory in spontaneously hypertensive rats (SHR, a recognised animal model of ADHD). Our preliminary findings indicate that, in comparison to normal rats, SHR make more mistakes on learning tasks, not because they are unable to remember, but because they cannot inhibit the wrong response. These rats also show abnormalities in the fatty acid composition of their brain, which may in turn be related to their behavioural problems through effects on specific chemical messengers. Thus we propose to supplement the diet of these rats with docosahexaenoic acid (DHA, an omega-3 fatty acid) to see whether we can improve their behavioural capabilities. The findings from these studies may have useful implications for the human conditions that they model.
与人类胎儿酒精综合征(FAS)和注意缺陷多动障碍(ADHD)相关的行为问题包括学习和记忆困难。我们使用动物模型来了解这些疾病背后的生物学机制,解决特定的膳食补充剂是否可能被证明是有用的预防和/或康复干预措施。我们已经表明,如果年轻的大鼠在大脑生长最快的时候暴露于乙醇中,它们将表现出与海马体基因表达变化相关的短期记忆障碍,与记忆储存有关的大脑区域。在幼鼠的饮食中增加胆碱的量已被证明会导致记忆增强和海马体中生长因子的增加。因此,我们建议检查这种饮食治疗是否会对酒精暴露大鼠的记忆过程产生有益的影响。为了达到这个目的,我们将给幼鼠喂食相当于重度“酗酒”孕妇所消耗的乙醇量,同时在它们的饮食中补充胆碱。我们预计这些大鼠在水迷宫中对隐藏的逃生平台的位置的短期记忆将比喂食乙醇的大鼠表现出更好的记忆,但不含胆碱;我们还预计饮食治疗将逆转在它们大脑中观察到的变化。我们还在完成一系列关于自发性高血压大鼠(SHR,公认的ADHD动物模型)学习和记忆的研究。我们的初步研究结果表明,与正常大鼠相比,SHR在学习任务中犯更多的错误,不是因为他们无法记住,而是因为他们无法抑制错误的反应。这些老鼠的大脑脂肪酸组成也显示出异常,这可能反过来与它们的行为问题有关,通过对特定化学信使的影响。因此,我们建议在这些大鼠的饮食中补充二十二碳六烯酸(DHA,一种omega-3脂肪酸),看看我们是否可以改善它们的行为能力。这些研究的发现可能对他们所模拟的人类状况有有用的影响。

项目成果

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Wainwright, Patricia其他文献

Wainwright, Patricia的其他文献

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{{ truncateString('Wainwright, Patricia', 18)}}的其他基金

Dietary supplementation in animal models of neurodevelopmental disorders
神经发育障碍动物模型中的膳食补充剂
  • 批准号:
    7617-2006
  • 财政年份:
    2007
  • 资助金额:
    $ 3.22万
  • 项目类别:
    Discovery Grants Program - Individual
Dietary supplementation in animal models of neurodevelopmental disorders
神经发育障碍动物模型中的膳食补充剂
  • 批准号:
    7617-2006
  • 财政年份:
    2006
  • 资助金额:
    $ 3.22万
  • 项目类别:
    Discovery Grants Program - Individual
Dietary essential fatty acis and ethanol: effects on brain and behavioural development
膳食必需脂肪酸和乙醇:对大脑和行为发育的影响
  • 批准号:
    7617-2001
  • 财政年份:
    2005
  • 资助金额:
    $ 3.22万
  • 项目类别:
    Discovery Grants Program - Individual
Dietary essential fatty acis and ethanol: effects on brain and behavioural development
膳食必需脂肪酸和乙醇:对大脑和行为发育的影响
  • 批准号:
    7617-2001
  • 财政年份:
    2004
  • 资助金额:
    $ 3.22万
  • 项目类别:
    Discovery Grants Program - Individual
Dietary essential fatty acis and ethanol: effects on brain and behavioural development
膳食必需脂肪酸和乙醇:对大脑和行为发育的影响
  • 批准号:
    7617-2001
  • 财政年份:
    2003
  • 资助金额:
    $ 3.22万
  • 项目类别:
    Discovery Grants Program - Individual
Dietary essential fatty acis and ethanol: effects on brain and behavioural development
膳食必需脂肪酸和乙醇:对大脑和行为发育的影响
  • 批准号:
    7617-2001
  • 财政年份:
    2002
  • 资助金额:
    $ 3.22万
  • 项目类别:
    Discovery Grants Program - Individual
Dietary essential fatty acis and ethanol: effects on brain and behavioural development
膳食必需脂肪酸和乙醇:对大脑和行为发育的影响
  • 批准号:
    7617-2001
  • 财政年份:
    2001
  • 资助金额:
    $ 3.22万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of prenatal ethanol exposure combined with dietary n-3 FA deficiency on central nervous system development
产前乙醇暴露联合膳食 n-3 FA 缺乏对中枢神经系统发育的影响
  • 批准号:
    7617-1997
  • 财政年份:
    2000
  • 资助金额:
    $ 3.22万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of prenatal ethanol exposure combined with dietary n-3 FA deficiency on central nervous system development
产前乙醇暴露联合膳食 n-3 FA 缺乏对中枢神经系统发育的影响
  • 批准号:
    7617-1997
  • 财政年份:
    1999
  • 资助金额:
    $ 3.22万
  • 项目类别:
    Discovery Grants Program - Individual
Effects of prenatal ethanol exposure combined with dietary n-3 FA deficiency on central nervous system development
产前乙醇暴露联合膳食 n-3 FA 缺乏对中枢神经系统发育的影响
  • 批准号:
    7617-1997
  • 财政年份:
    1998
  • 资助金额:
    $ 3.22万
  • 项目类别:
    Discovery Grants Program - Individual

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