The role of the polarity protein, Par3, in haematopoiesis and leukaemogenesis

极性蛋白 Par3 在造血和白血病发生中的作用

• 批准号: nhmrc : GNT1100567
• 负责人: A/Pr Sarah Ellis
• 金额: $ 58.98万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-polarity-protein-haematopoiesis-leukaemogenesis/1346126
• 关键词: role; polarity; protein; Par3; haematopoiesis

Understanding the factors regulating blood production is critical to understanding how blood cancers occur and for the development of new therapies. Evidence is emerging of a vital role for the evolutionary conserved ‘polarity’ proteins in blood production and leukaemia This project will elucidate the role of the polarity protein, Par3, in normal and malignant blood cells, providing valuable insight into how Par3 regulates blood formation and the onset and severity of leukaemia.

了解调节血液生成的因素对于了解血癌如何发生和开发新疗法至关重要。有证据表明，进化保守的“极性”蛋白在血液生成和白血病中起着至关重要的作用。该项目将阐明极性蛋白Par3在正常和恶性血细胞中的作用，为Par3如何调节血液形成以及白血病的发作和严重程度提供有价值的见解。