Cell pedigree tracking to elucidate how polarity proteins alter fate in B-cell development and leukaemia.

细胞谱系追踪可阐明极性蛋白如何改变 B 细胞发育和白血病的命运。

• 批准号: nhmrc : 1035991
• 负责人: A/Pr Sarah Ellis
• 金额: $ 20.53万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-pedigree-tracking-development-leukaemia/110994
• 关键词: Cell; pedigree; tracking; elucidate; how

During the onset of cancer, the orientation of cells is lost. My research project aims to determine the cellular and molecular basis by which proteins responsible for the orientation of cells are involved in leukaemia. Additionally, my work will investigate whether or not all proteins are equally distributed during cell division in B cell development, and will provide a platform for further investigation into how protein distribution might orchestrate fate decisions during development and leukaemia.

在癌症的发病过程中，细胞的方向会丢失。我的研究项目旨在确定负责细胞定位的蛋白质参与白血病的细胞和分子基础。此外，我的工作将调查在B细胞发育的细胞分裂过程中，所有蛋白质是否均匀分布，并将为进一步研究蛋白质分布如何协调发育和白血病期间的命运决定提供一个平台。