Sea lice resistance to avermectins

海虱对阿维菌素的抗性

• 批准号: 36362-2006
• 负责人: Burka, John
• 金额: $ 1.96万
• 依托单位: University of Prince Edward Island
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=390113
• 关键词: Sea; lice; resistance; avermectins

The Long Term Goal of this program is to develop strategies to identify, monitor, and control resistance of sea lice to therapeutants used in salmonid aquaculture with a focus on increasing our knowledge of sea lice biology, especially as it relates to sea lice-salmon interactions so that sea lice can be controlled more effectively.  The Short-Term Objective is to increase our understanding of the mechanisms of action of the avermectin, emamectin benzoate (EMB; SLICE), currently the predominant drug used for sea lice control. This study will enhance our understanding of how avermectins act in sea lice and how drug resistance can develop.  This is a basic research program with applications directly relevant to the salmonid aquaculture industry. Specific goals are to further understand how the drug gets from the salmon skin to the target site in sea lice and how this transport is controlled.  We also want to know exactly how the avermectins kill sea lice and want to know more about the target site.  Both these parameters also have implications in resistance development. Decreased uptake would lead to less drug available at the target site and thus decreased efficacy.  Changes in receptor structure would also result in decreased efficacy. Understanding the mechanisms of avermectin action may provide the basis for novel drug development for sea lice control, especially if the target for avermectins is different than for other arthropods.  Increased understanding of sea lice resistance mechanisms would allow for more rapid detection of resistance development as well as improved therapeutic strategies.

该项目的长期目标是制定策略，以识别、监测和控制海虱对鲑鱼养殖中使用的治疗剂的抗性，重点是增加我们对海虱生物学的知识，特别是当它涉及到海虱-鲑鱼相互作用时，以便更有效地控制海虱。短期目标是增加我们对阿维菌素作用机制的理解，甲氨基阿维菌素苯甲酸盐（EMB; SLICE），目前用于海虱控制的主要药物。这项研究将提高我们对阿维菌素如何作用于海虱以及耐药性如何发展的理解。这是一项与鲑鱼水产养殖业直接相关的基础研究计划。具体目标是进一步了解药物如何从鲑鱼皮到达海虱的目标部位，以及如何控制这种运输。我们还想确切地知道阿维菌素如何杀死海虱，并想了解更多关于目标部位的信息。这两个参数也对耐药性的发展有影响。摄取减少会导致靶点可用药物减少，从而降低疗效。受体结构的变化也会导致疗效降低。了解阿维菌素的作用机制可能为开发新的药物控制海虱提供基础，特别是如果阿维菌素的靶点与其他节肢动物不同，增加对海虱抗性机制的了解将允许更快速地检测抗性发展以及改进的治疗策略。