The Role of Redox Regulation in Controlling the Oncogenic Function of Eph Receptors

癌症中产生的活性氧物种(ROS)激活了细胞表面受体信号通路，从而推动癌症的进展。我将研究癌细胞中ROS和受体信号之间的联系，并用纳米颗粒中传递的ROS清除剂抑制信号传递，目标是与特定抗体的受体复合体。这些将包括我们针对ADAM10产生的抗体，ADAM10是一种与多个受体信号通路相关的蛋白酶，以同时抑制这些途径。

Reactive oxygen species (ROS) produced in cancers activate cell surface receptor signalling pathways that drive cancer progression. I will study links between ROS and receptor signalling in cancer cells, and inhibit signalling with ROS scavengers delivered in nanoparticles, targeted to receptor complexes with specific antibodies. These will include antibodies we raised against ADAM10, a protease associated with multiple receptor signalling pathways, to simultaneously inhibit these pathways.