Role of spontaneous activity in the formation of functional cortical circuits in vivo.

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Neurons in the brain wire together to from circuits that underpin brain function. In order to wire correctly, cortical neurons rely on spontaneous activity, where ensembles of neurons fire in specific patterns, to find and form their correct cortical circuits. This project aims to understand how spontaneous cortical activity regulates brain wiring and cortical development. The work will inform our understanding of neurodevelopmental disorders and ways to optimise brain development.