The role of STAT3 in human CD8+ T cell function

STAT3在人CD8 T细胞功能中的作用

• 批准号: nhmrc : 1027400
• 负责人: Dr Elissa Deenick
• 金额: $ 36.23万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-stat3-human-cell-function/110566
• 关键词: role; STAT3; human; CD8+; cell

CD8+ T cells provide us with protection against viruses and can also mediate potent anti-tumour effects. Understanding the signals that initiate and sustain an effective CD8+ T cell response is important if we are to intervene in diseases where CD8+ T cell function is defective. We will study patients with inherited gene defects that disrupt some of the signals that T cells receive to determine the role those signals usually play in instructing CD8+ T cells to fight viral infection.

CD8+ T细胞为我们提供抗病毒保护，也可以介导有效的抗肿瘤作用。如果我们要干预CD8 + T细胞功能缺陷的疾病，那么了解启动和维持有效CD8 + T细胞应答的信号非常重要。我们将研究具有遗传基因缺陷的患者，这些基因缺陷破坏了T细胞接收的一些信号，以确定这些信号通常在指导CD8+ T细胞对抗病毒感染中发挥的作用。