STAT3-mediated regulation of human antibody responses

STAT3介导的人类抗体反应调节

• 批准号: nhmrc : 1066694
• 负责人: Dr Elissa Deenick
• 金额: $ 38.69万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stat3-mediated-regulation-antibody-responses/455253
• 关键词: STAT3; mediated; regulation; human; antibody

The immune system rapidly responds to infectious pathogens to eradicate such microbes and limit the damage they can inflict upon the host. Individuals with primary immunodeficiencies have defects in the development and/or function of the cells of their immune system and are more susceptible to infectious diseases. This study will investigate such individuals to identify functions for specific genes and immune cells in order to understand the requirements for generating effective immune responses.

免疫系统对传染性病原体迅速作出反应，消灭这些微生物，限制它们对宿主造成的损害。具有原发性免疫缺陷的个体在其免疫系统细胞的发育和/或功能方面存在缺陷，并且更容易感染传染病。本研究将对这些个体进行调查，以确定特定基因和免疫细胞的功能，从而了解产生有效免疫反应的要求。