Role of the tissue kallikrein-kinin system in abdominal aortic aneurysm formation and progression

组织激肽释放酶-激肽系统在腹主动脉瘤形成和进展中的作用

• 批准号: nhmrc : 540403
• 负责人: A/Pr Catherine Rush
• 金额: $ 30.52万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-tissue-kallikrein-formation-progression/99285
• 关键词: Role; tissue; kallikrein; kinin; system

Up to 5% of people over 60 years develop weakening of their aorta leading to slow dilation of the vessel, which may burst resulting in sudden death. The only treatment is surgery, which has complications and is unsuitable for some patients. Drugs which slow the disease would be invaluable. We have identified a role for kinins in aneurysms. We will investigate how these molecules contribute to aortic disease and if blocking them can be used as a basis for medical treatment of artery weakening.

60岁以上的人中，高达5%的人会出现主动脉变弱，导致血管缓慢扩张，血管可能会破裂，导致猝死。唯一的治疗方法是手术，手术有并发症，不适合某些患者。减缓疾病的药物将是无价的。我们已经确定了激肽在动脉瘤中的作用。我们将研究这些分子是如何导致主动脉疾病的，以及阻断它们是否可以作为动脉衰弱的医学治疗的基础。