The role of the clotting cascade in aortic aneurysm and associated cardiovascular events

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Weakening of the main abdominal artery is responsible for approximately 1000 deaths/ year in Australia. Most weakened arteries are identified at an early stage but there is no current therapy which limits the progression of artery weakening. There is also no model which predicts the complications associated with weakened arteries. In the current project we propose the importance of clot in progression and complications of weakened arteries. We will undertake studies to identify new therapies and a predictive model for weakened arteries.