The role of vasoactive hormones in the pathogenesis of hepatic fibrosis

血管活性激素在肝纤维化发病机制中的作用

• 批准号: nhmrc : 181300
• 负责人: Prof Louise Burrell
• 金额: $ 18.09万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-vasoactive-hormones-hepatic-fibrosis/83050
• 关键词: role; vasoactive; hormones; pathogenesis; hepatic

One of the most important consequences of chronic liver disease is the development of progressive liver fibrosis or scarring. This process is responsible for many of the life-threatening complications of liver disease, however, the mechanisms responsible are not completely understood and there are no established treatments. The aetiologies of cirrhosis, or scarring of the liver, are many and vary from viral hepatitis to inherited and autoimmune disorders. Regardless of the cause, it appears that fibrosis develops down a common pathway leading to eventual cirrhosis. We will study the pathways that are thought to be involved in the stimulation of liver scarring, in particular, focusing on those that lead to its activation and perpetuation. It is hypothesised that these pathways will prove to be potential targets for the treatment and prevention of liver fibrosis.

慢性肝病最重要的后果之一是进展性肝纤维化或瘢痕形成。这一过程导致了许多危及生命的肝脏疾病并发症，然而，其机制尚不完全清楚，也没有确定的治疗方法。肝硬化或肝脏瘢痕形成的病因很多，从病毒性肝炎到遗传性和自身免疫性疾病不一而足。无论病因如何，纤维化似乎沿着一条导致最终肝硬化的共同途径发展。我们将研究被认为与肝瘢痕形成的刺激有关的途径，特别是那些导致其激活和延续的途径。据推测，这些途径将被证明是治疗和预防肝纤维化的潜在靶点。