The role of vasoactive hormones in progressive liver disease

血管活性激素在进行性肝病中的作用

• 批准号: nhmrc : 350384
• 负责人: Prof Louise Burrell
• 金额: $ 30.26万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-vasoactive-hormones-liver-disease/99081
• 关键词: role; vasoactive; hormones; progressive; liver

Cirrhosis of the liver is a leading cause of morbidity and mortality in our community and its prevalence is rising due to the increasing impact of chronic viral hepatitis infection. While the advent of effective antiviral therapies will have some benefit in reducing this disease burden, there remains a major need to develop treatments that can prevent and treat cirrhosis of the liver and its clinical sequelae. We believe that overactive hormone systems may play a role in disease of the liver. The planned studies will involve compounds that block the formation or the action of hormones which cause scarring of the liver. The results may lead to new treatments for cirrhosis of the liver.

肝硬变是我们社会发病率和死亡率的主要原因，由于慢性病毒性肝炎感染的影响越来越大，其患病率正在上升。虽然有效的抗病毒疗法的出现将对减轻这种疾病的负担有一定的好处，但仍然需要开发能够预防和治疗肝硬变及其临床后遗症的治疗方法。我们认为，过度活跃的激素系统可能在肝脏疾病中发挥作用。计划中的研究将涉及阻止荷尔蒙的形成或作用的化合物，荷尔蒙会导致肝脏瘢痕形成。这一结果可能会导致治疗肝硬变的新方法。