The role of Vitamin D in determining risk of developing juvenile idiopathic arthritis

维生素 D 在确定幼年特发性关节炎发生风险中的作用

• 批准号: nhmrc : 1026349
• 负责人: A/Pr Justine Ellis
• 金额: $ 39.11万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-vitamin-d-idiopathic-arthritis/110488
• 关键词: role; Vitamin; determining; risk; developing

Juvenile Idiopathic arthritis (JIA) is an autoimmune disease that occurs in up to 1/250 Australian children. Growing evidence suggests that low vitamin D increases risk of autoimmune disease, yet no-one has looked at its effect on JIA. We will compare vitamin D in blood, and also exposure to sun through life, between children with and without JIA. We will also look to see if vitamin D interacts with autoimmune disease risk genes. The outcomes of this study will help to inform policy on the importance of sun exposure to health.

幼年特发性关节炎（JIA）是一种自身免疫性疾病，发生在多达1/250的澳大利亚儿童中。越来越多的证据表明，低维生素D会增加自身免疫性疾病的风险，但没有人研究过它对JIA的影响。我们将比较血液中的维生素D，也暴露在阳光下通过生活，儿童与非JIA之间。我们还将观察维生素D是否与自身免疫性疾病风险基因相互作用。这项研究的结果将有助于为阳光照射对健康的重要性提供政策信息。