The roles of EZH2 and FOXO1A in CNS-PNET pathogenesis.

EZH2 和 FOXO1A 在 CNS-PNET 发病机制中的作用。

• 批准号: nhmrc : 403983
• 负责人: Dr Peter Dallas
• 金额: $ 31.17万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/roles-ezh2-foxo1a-pnet-pathogenesis/76642
• 关键词: roles; EZH2; FOXO1A; CNS; PNET

Although CNS-PNETs are the most common embryonal CNS tumours of childhood and cause significant mortality and morbidity, there is a very limited understanding of the pathogenesis of this aggressive disease. This situation is a major handicap to the development of more specific and effective therapies. While a better understanding of the fundamental pathology of CNS-PNETs will have immediate diagnostic implications, the elucidation of the biochemical pathways that are disrupted in these tumours will facilitate the design of new drugs that are specifically directed towards the critical proteins in these pathways. The identification of specific genes and-or pathways that are deregulated in CNS-PNET cells is essential for the development of safer, more directed, and more effective therapies that are urgently required for the treatment of those with this devastating disease.

虽然中枢神经系统-神经母细胞瘤是最常见的胚胎中枢神经系统肿瘤的儿童，并导致显着的死亡率和发病率，有一个非常有限的了解这种侵略性疾病的发病机制。这种情况是发展更特异和有效疗法的主要障碍。虽然更好地了解CNS-PNS的基本病理学将具有直接的诊断意义，但阐明这些肿瘤中被破坏的生化途径将有助于设计专门针对这些途径中关键蛋白质的新药。鉴定CNS-PNET细胞中失调的特定基因和/或途径对于开发更安全，更直接，更有效的治疗方法至关重要，这些治疗方法迫切需要治疗这种毁灭性疾病。