Salt, opiates and addiction

盐、阿片类药物和成瘾

• 批准号: nhmrc : 1079891
• 负责人: Dr Stuart Mcdougall
• 金额: $ 37.68万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/salt-opiates-addiction/518707
• 关键词: Salt; opiates; addiction

Salt (sodium) is an essential electrolyte. Our convincing and complementary findings provide compelling evidence for a link between evolutionarily ancient “instincts” and substance abuse. This proposal is translational, including studies in opiate dependent humans. Our studies will establish how and where in the brain endogenous opioids are implicated in the gratification of salt appetite, how salt appetite is altered in opiate dependency and if salt appetite recovers following opiate withdrawal

盐（钠）是一种重要的电解质。我们令人信服的和互补的发现提供了令人信服的证据，证明进化上古老的“本能”和药物滥用之间的联系。这项建议是翻译，包括在阿片类药物依赖的人的研究。我们的研究将确定内源性阿片样物质在大脑中的位置和方式与盐食欲的满足有关，阿片依赖如何改变盐食欲，以及阿片戒断后盐食欲是否恢复