Individual differences in nicotine dependence: A multi-modal neuroimaging approach

尼古丁依赖的个体差异：多模式神经影像学方法

• 批准号: 9381306
• 负责人: Amy C Janes
• 金额: $ 13.92万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9381306
• 关键词: Address; Anterior; Behavioral; Biological Markers; Brain; Brain region; Cocaine; Collaborations; Conflict (Psychology); Coupling; Cues; Dependency; Detection; Development; Dorsal; Educational process of instructing; Electroencephalography; Electronic cigarette; Emotional; Equilibrium; Event-Related Potentials; Failure; Foundations; Frequencies; Functional Magnetic Resonance Imaging; Funding; Goals; Imaging Techniques; Individual; Individual Differences; Insula of Reil; Investigation; K-Series Research Career Programs; Laboratories; Laboratory Research; Left; Link; Magnetic Resonance Spectroscopy; Measures; Mental disorders; Mentors; Mission; Modality; Monitor; Neurobiology; Neurons; Nicotine Dependence; Opiates; Outcome; Phase; Prefrontal Cortex; Process; Recruitment Activity; Relapse; Reporting; Research; Research Training; Rest; Risk Factors; Role; Scientist; Signal Transduction; Smoker; Smoking; Solid; Techniques; Testing; Time; Treatment Failure; Wages; Work; addiction; cingulate cortex; cognitive control; cost; cue reactivity; density; emotion dysregulation; executive function; gamma-Aminobutyric Acid; improved; interest; millisecond; neurobiological mechanism; neuroimaging; nicotine replacement; novel; personalized medicine; programs; relapse prediction; relating to nervous system; skills; source localization; spatiotemporal; temporal measurement; therapeutic target; treatment strategy; undergraduate student

Abstract This application is for a new K02 Independent Scientist Career Development Award that seeks five years of protected time to solidify my newly established independent laboratory the Functional Integration of Addiction Research Laboratory. My laboratory focuses on defining individual risk factors for addictive disorders and their related neurobiological mechanisms and is supported by my funded R01 (DA039135; July 2015-2020). The 5 years of protected time afforded by this K02 will facilitate this project's objectives by allowing me to (1) acquire new skills in high-density electroencephalography (EEG/ERP) in conjunction with advanced source localization techniques, and thus enable investigation of the spatio-temporal dynamics of mechanisms underlying addiction; (2) mentor junior scientists; and (3) extend my research portfolio through collaborations. My research to date has employed functional magnetic resonance imaging (fMRI), which in many cases can answer similar questions as EEG. However, EEG has greater temporal resolution (on the order of milliseconds) than fMRI (seconds) allowing for superior analysis of the spatiotemporal dynamics of brain mechanisms. Such relationships can provide important clues regarding processes that go awry in those with addictive disorders. Specifically, the proposed EEG collaboration will fundamentally extend the research objectives of my funded R01 by identifying the neurobiological aspect of cognitive control disrupted in those who have difficulty ignoring smoking cues, which is related to relapse vulnerability. In addition, through other planned collaborations I will expand my research of smoking cue reactivity and nicotine dependence to include research into other addictions (i.e., cocaine and opiates) and other risk factors for addiction (co-morbid psychiatric disorders). In the absence of key protected K02 support, I would need to cover the balance of my salary through teaching at the undergraduate level and committee work, which would significantly detract from these activities that are key to a newly independent scientist.

摘要 此应用程序是一个新的K 02独立科学家职业发展奖，寻求五年的 保护时间来巩固我新成立的独立实验室成瘾的功能整合 研究实验室。我的实验室专注于定义成瘾性疾病的个体风险因素及其 相关的神经生物学机制，并由我资助的R 01（DA 039135; 2015年7月至2020年）支持。的5 多年的保护时间提供了这个K 02将促进这个项目的目标，让我（1）获得 高密度脑电描记术（EEG/ERP）的新技能与先进的源定位相结合 技术，从而能够研究潜在机制的时空动态 成瘾;（2）指导初级科学家;（3）通过合作扩展我的研究组合。我的研究 到目前为止，已经使用了功能性磁共振成像（fMRI），在许多情况下，它可以回答类似的问题。 问EEG。然而，EEG比fMRI具有更高的时间分辨率（毫秒级 （秒）允许对大脑机制的时空动力学进行高级上级分析。等 人际关系可以提供重要的线索，帮助我们了解成瘾性疾病患者的心理过程。 具体来说，拟议中的EEG合作将从根本上扩展我资助的研究目标。 R 01通过识别那些难以忽视的人的认知控制的神经生物学方面， 吸烟暗示，这与复发的脆弱性有关。此外，通过其他计划中的合作，我将 扩展我对吸烟提示反应和尼古丁依赖的研究，包括对其他 成瘾（即，可卡因和阿片类药物）和其他成瘾风险因素（共病精神障碍）。在 由于没有关键的受保护的K 02支持，我需要通过在 本科生水平和委员会的工作，这将大大减损这些活动， 一位新独立科学家的关键