Individual differences in nicotine dependence: A multi-modal neuroimaging approach

摘要 本申请表为新的K02独立科学家职业发展奖，旨在寻求五年的 保护时间巩固我新成立的独立实验室成瘾的功能整合 研究实验室。我的实验室专注于定义成瘾障碍的个人风险因素及其 相关的神经生物学机制，并得到我资助的R01(DA039135；2015-2020年7月)的支持。5. K02所提供的多年保护时间将使我能够(1)获得 结合先进震源定位的高密度脑电(EEG/ERP)新技术 技术，从而能够研究基础机制的时空动力学 (2)指导初级科学家；(3)通过合作扩大我的研究范围。我的研究 到目前为止，已经使用了功能磁共振成像(FMRI)，在许多情况下可以回答类似的问题 作为脑电检查的问题。然而，与fMRI相比，EEG具有更高的时间分辨率(在毫秒量级 (秒)，从而能够更好地分析大脑机制的时空动力学。是这样的 人际关系可以为那些患有成瘾障碍的人提供有关过程出错的重要线索。 具体地说，拟议的EEG合作将从根本上扩展我资助的 R01通过识别认知控制的神经生物学方面在那些难以忽视的人中被扰乱 吸烟提示，这与复发易感性有关。此外，通过其他计划的协作，我将 扩展我对吸烟线索反应性和尼古丁依赖的研究，将其他研究包括在内 成瘾(即可卡因和鸦片类药物)和其他成瘾风险因素(共病精神障碍)。在……里面 由于缺少K02的关键保护支持，我需要通过在 本科水平和委员会工作，这将大大有损于这些活动，这些活动是 一位新独立科学家的关键。

Abstract This application is for a new K02 Independent Scientist Career Development Award that seeks five years of protected time to solidify my newly established independent laboratory the Functional Integration of Addiction Research Laboratory. My laboratory focuses on defining individual risk factors for addictive disorders and their related neurobiological mechanisms and is supported by my funded R01 (DA039135; July 2015-2020). The 5 years of protected time afforded by this K02 will facilitate this project's objectives by allowing me to (1) acquire new skills in high-density electroencephalography (EEG/ERP) in conjunction with advanced source localization techniques, and thus enable investigation of the spatio-temporal dynamics of mechanisms underlying addiction; (2) mentor junior scientists; and (3) extend my research portfolio through collaborations. My research to date has employed functional magnetic resonance imaging (fMRI), which in many cases can answer similar questions as EEG. However, EEG has greater temporal resolution (on the order of milliseconds) than fMRI (seconds) allowing for superior analysis of the spatiotemporal dynamics of brain mechanisms. Such relationships can provide important clues regarding processes that go awry in those with addictive disorders. Specifically, the proposed EEG collaboration will fundamentally extend the research objectives of my funded R01 by identifying the neurobiological aspect of cognitive control disrupted in those who have difficulty ignoring smoking cues, which is related to relapse vulnerability. In addition, through other planned collaborations I will expand my research of smoking cue reactivity and nicotine dependence to include research into other addictions (i.e., cocaine and opiates) and other risk factors for addiction (co-morbid psychiatric disorders). In the absence of key protected K02 support, I would need to cover the balance of my salary through teaching at the undergraduate level and committee work, which would significantly detract from these activities that are key to a newly independent scientist.