Investigation of the biological effects of the polyphenol resveratrol on insulin producing and insulin target tissues

多酚白藜芦醇对胰岛素产生和胰岛素靶组织的生物学效应研究

• 批准号: 301047-2007
• 负责人: Tsiani, Evangelia
• 金额: $ 1.17万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Group
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=396299
• 关键词: Investigation; biological; effects; polyphenol; resveratrol

Polyphenols are compounds found in the skin of grapes and in high concentration in red wine. Many studies have shown that polyphenols have various beneficial health effects including protection against cancer and cardiovascular disease. Insulin is a hormone that plays a major role in regulating the blood glucose levels. When the blood glucose levels are increased, insulin is released by the pancreas and through the bloodstream acts on liver cells inhibiting glucose production and release as well as on muscle cells causing them to take up glucose from the blood. The net effect of these insulin actions is to bring the blood glucose levels back to normal. Resistance to insulin in combination with decreased pancreatic function leads to type 2 diabetes. Elevated free fatty acids in the blood, as seen in obesity, have been shown to cause insulin resistance and pancreatic impairment.

多酚是一种在葡萄皮中发现的化合物，在红葡萄酒中含量很高。许多研究表明，多酚对健康有多种有益作用，包括预防癌症和心血管疾病。胰岛素是一种荷尔蒙，在调节血糖水平方面起着重要作用。当血糖水平升高时，胰岛素由胰腺释放，并通过血流作用于肝细胞，抑制葡萄糖的产生和释放，并作用于肌肉细胞，使其从血液中吸收葡萄糖。这些胰岛素作用的净效果是使血糖水平恢复正常。胰岛素抵抗加上胰腺功能下降会导致2型糖尿病。血液中游离脂肪酸的升高，如肥胖所见，已被证明会导致胰岛素抵抗和胰腺损伤。