Enantioselective catalyis and total synthesis of alkaloids

我们正在开发合成手性化合物的新方法。手性化合物在制药和精细化工行业中都非常重要。例如，手性药物的全球销售额远远超过1000亿美元。提议的nserc资助研究的前半部分侧重于开发新型手性催化剂。发现更好的催化剂对于改进上述化合物的制备方法至关重要。最终，我们的研究，如果被证明是成功的，可能会降低人类药品和其他重要化学品的生产成本。我们NSERC提案的后半部分描述了一种新的合成途径，可以合成一类在人类中表现出非常有希望的治疗特性的分子。这一领域的研究可能有一天会导致治疗严重疾病的更好药物的开发。NSERC拨款还用于培训制药和其他相关化学工业所需的高素质化学家。

We are developing new methods for the synthesis of chiral compounds. Chiral compounds are extremely important to both the pharmaceutical and fine chemical industries. For example, worldwide sales of chiral drugs are well over a hundred billion dollars. The first half of proposed NSERC-funded research focuses on the development of new classes of chiral catalysts. The discovery of better catalysts is crucial to improving the ways in which the afore-mentioned compounds can be made. Ultimately, our research, if proven successful, might be able to lower the cost of manufacturing human pharmaceuticals and other important chemicals. The second half of our NSERC proposal delineates a new synthetic route to a class of molecules that exhibit very promising therapeutic properties in humans. Research in this field might one day lead to the development of better medicines for the treatment of serious ailments. The NSERC grant also enables the training of highly qualified chemists that are required in the pharmaceutical and other allied chemical industries.