Enantioselective catalyis and total synthesis of alkaloids

对映选择性催化和生物碱的全合成

• 批准号: 311670-2008
• 负责人: Thadani, Avinash
• 金额: $ 0.45万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=457091
• 关键词: Enantioselective; catalyis; total; synthesis; alkaloids

We are developing new methods for the synthesis of chiral compounds. Chiral compounds are extremely important to both the pharmaceutical and fine chemical industries. For example, worldwide sales of chiral drugs are well over a hundred billion dollars. The first half of proposed NSERC-funded research focuses on the development of new classes of chiral catalysts. The discovery of better catalysts is crucial to improving the ways in which the afore-mentioned compounds can be made. Ultimately, our research, if proven successful, might be able to lower the cost of manufacturing human pharmaceuticals and other important chemicals. The second half of our NSERC proposal delineates a new synthetic route to a class of molecules that exhibit very promising therapeutic properties in humans. Research in this field might one day lead to the development of better medicines for the treatment of serious ailments. The NSERC grant also enables the training of highly qualified chemists that are required in the pharmaceutical and other allied chemical industries.

我们正在开发合成手性化合物的新方法。 手性化合物在医药和精细化工领域都具有极其重要的意义。 例如，手性药物的全球销售额远远超过1000亿美元。 NSERC资助的研究的前半部分集中在开发新的手性催化剂上。 发现更好的催化剂对于改进上述化合物的制备方法至关重要。 最终，我们的研究如果被证明是成功的，也许能够降低人类药物和其他重要化学品的制造成本。 我们的NSERC提案的后半部分描绘了一类在人类中表现出非常有希望的治疗特性的分子的新合成路线。 这一领域的研究可能有一天会导致开发出更好的药物来治疗严重疾病。 NSERC赠款还可以培训制药和其他相关化学工业所需的高素质化学家。