Interactions of early rearing and later environment on brain self-repair and compensation

早期养育与后期环境的相互作用对大脑自我修复和补偿的影响

• 批准号: 331194-2006
• 负责人: Kraemer, Gary
• 金额: $ 1.48万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=398192
• 关键词: Interactions; early; rearing; later; environment

The area that this research is most clearly relevant to is that of developmental psychopathology in humans. The questions are: "Why doesn't the central nervous system and behavior recover from early social environmental privation after the individual is introduced to an optimal and even therapeutic environment in many cases? Why do drug treatments help ameliorate the symptoms of psychopathology, but rarely effect a cure." The focus of the proposed studies is an outgrowth and continuation of studies in non-human primates. The overall aim of this project is to identify the circumstances and then the neurobiological mechanisms by which experiences later in life can substantially reverse the adverse behavioral effects of privation of maternal care in the rat. That is, "self-repair" - the mechanisms by which the central nervous system (CNS) and the organism as a whole recovers from early deprivation, and the environmental factors that can promote or limit this process. The proposed project invloves the study of rat pups reared either by their mothers or in conditions comparable to a human neonatal intensive care unit, and then in standard laboratory or socially complex environments. Changes in the brain related to behavior will be investigated at the neuroanatomical and cellular level. An important goal is to understand how therapeutic drugs might interact with environmental factors that cause changes in brain mechanisms. The overall objective is to discover why self repair is often uncertain or incomplete, and then how to promote this process.

这项研究最明显相关的领域是人类的发展精神病理学。这些问题是：为什么在许多情况下，当个体被引入到一个最佳甚至是治疗性的环境中时，中枢神经系统和行为并没有从早期的社会环境中恢复过来？为什么药物治疗有助于改善精神病理学的症状，但很少有效治愈。“拟议研究的重点是非人类灵长类动物研究的结果和继续。该项目的总体目标是确定的情况下，然后在生命后期的经验，可以大大扭转不利的行为影响的母亲照顾的大鼠的神经生物学机制。也就是说，“自我修复”-中枢神经系统（CNS）和整个生物体从早期剥夺中恢复的机制，以及可以促进或限制这一过程的环境因素。拟议的项目涉及对幼鼠的研究，这些幼鼠要么由母亲抚养，要么在与人类新生儿重症监护室相当的条件下抚养，然后在标准实验室或社会复杂环境中抚养。将在神经解剖学和细胞水平上研究与行为相关的大脑变化。一个重要的目标是了解治疗药物如何与引起大脑机制变化的环境因素相互作用。总的目标是发现为什么自我修复往往是不确定的或不完整的，然后如何促进这一进程。