Fetal endotoxin exposure and regulation of amino acid supply

胎儿内毒素暴露与氨基酸供应的调节

• 批准号: 341265-2008
• 负责人: Regnault, Timothy
• 金额: $ 1.91万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=399296
• 关键词: Fetal; endotoxin; exposure; regulation; amino

Maternal dietary, environment and pathogen-induced stress during pregnancy are important factors contributing to animal growth during pregnancy, survival after birth and postnatal health. In particular, pathogen-induced bacterial infections result in significant losses to agriculture. Treatment of healthy pregnant animals with bacterial cell wall components, termed lipopolysaccharide (LPS) provides an important approach for modeling how infection adversely affects pregnancy outcomes. Exposure to LPS in fetal life, results in fetal growth restriction (low birth weight outcomes) and animal losses. Additionally, in postnatal animals, LPS exposure affects skeletal muscle development providing a basis for reduced protein development; however this mechanism has not yet been established to occur during fetal development.

妊娠期母体的饮食、环境和病原体引起的应激是影响动物妊娠期生长、出生后存活和产后健康的重要因素。特别是，病原体诱导的细菌感染对农业造成重大损失。用细菌细胞壁成分（称为脂多糖（LPS））治疗健康妊娠动物提供了一种重要的方法来模拟感染如何对妊娠结局产生不利影响。在胎儿生命中暴露于LPS，导致胎儿生长受限（低出生体重结果）和动物损失。此外，在出生后的动物中，LPS暴露影响骨骼肌发育，为蛋白质发育减少提供了基础;然而，这种机制尚未确定在胎儿发育期间发生。