Immune system involvement in skeletal muscle adaptation to contractile activity during human growth

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Most people would agree that exercise for children is essential, but recent statistics tell us that 3 out of 5 Canadian children are not active enough for optimal growth and development, which this proposal defines as the healthy function of tissues (e.g., skeletal muscle). The problems are that 1) the type of exercise that best promotes tissue health in children is unknown, and 2) we do not fully understand the mechanisms that translate exercise into optimal tissue function during human growth. What we do know is that exercise in children activates immune factors with the capacity to benefit tissue function.