Sleep-wake disturbances and cardio-metabolic dysfunction in at risk dementia: a novel pathway in neurocognitive decline’

与年龄相关的睡眠和昼夜节律紊乱以及心脏代谢功能障碍与痴呆症的风险增加有关。这项研究的目的是描述睡眠和昼夜节律紊乱以及心脏代谢障碍在高危痴呆症阶段促进认知下降的途径。这将提高我们对认知老化关键过程的理解，最终导致开发有针对性的干预计划，以寻求延迟痴呆症的发生。

Age-related sleep and circadian disturbance and cardio-metabolic dysfunction are associated with an increased risk of dementia. This research aims to delineate the pathway in which sleep and circadian disturbances and cardio-metabolic dysfunction promote cognitive decline during the ‘at risk’ dementia phase. This will improve our understanding of key processes in cognitive ageing ultimately leading to the development of targeted intervention programs in the quest to delay the onset of dementia.