Sleep-Wake Cycles of Individuals with Inflammatory Bowel Disease

项目总结 Ruth L.Kirschstein国家研究服务奖(NRSA)个人博士前研究的目的 护理学研究奖学金(F31)的申请是为Yoo女士提供研究培训的一个开始 华盛顿大学(UW)二年级博士生。此次培训的长期目标是 俞敏洪女士将在研究密集型学术环境中发展成为一名独立研究员，她的项目是 研究重点是通过改善炎症性肠病(IBD)患者的健康状况 制定处理生物和社会生态因素的自我管理战略。所需成本 IBD是一种慢性胃肠道(GI)疾病，在美国的护理和患病率一直在上升。IBD 症状(如腹泻、腹痛)对生活质量、工作效率和学校都有负面影响 出席；因此，显然需要探索行为改变(例如，影响行为的睡眠-觉醒 周期)，以减轻IBD患者的症状。尽管动物模型已经显示出 胃肠道系统的睡眠-觉醒周期被打乱(例如，肠道生物失调)，很少有研究集中在 睡眠-觉醒周期不一致对IBD健康结局的影响以及外部社会生态的作用 影响IBD患者睡眠-觉醒周期的因素(例如，工作和家庭义务)。建议的目标是 研究采用定量和定性相结合的方法，旨在了解休息与心理健康之间的关系。 活动节律(RAR)特征和社交时差与疲劳、睡眠质量、胃肠道症状和疾病的关系 活动，并确定影响睡眠-醒来周期的社会和社会因素。与大多数IBD睡眠不同 研究中，这项研究将使用客观活动图来测量RAR和社会时差，定性的一部分将 提供IBD参与者对影响睡眠-觉醒周期的社会生态因素的更多见解 量化措施不能完全涵盖。健康和睡眠的社会生态模型将指导 研究项目考虑睡眠-觉醒周期对IBD的社会、社会和个人水平的影响 结果。首席调查员将收集来自加州大学的24名IBD参与者的预期数据。 华盛顿医疗中心的胃肠病诊所，并利用现有的来自 之前的研究重点是夜间睡眠结果，结果总共有50名参与者。这一奖项将 通过高级课程和直接的研究经验，质的和 定量方法，集中分析RAR，并发现三个不同的 与睡眠-觉醒周期和IBD相关健康结局相关的概念。由此产生的发现 调查将为建立新的自我管理研究计划提供基础知识 以及IBD的症状科学。

PROJECT SUMMARY The purpose of this Ruth L. Kirschstein National Research Service Award (NRSA) Individual Pre-Doctoral Fellowship in Nursing Research (F31) application is to provide research training for Ms. Yoo, a beginning second-year doctoral student at the University of Washington (UW). The long-term goal of this training is for Ms. Yoo to develop into an independent researcher at a research-intensive academic setting with a program of research focused on improving health outcomes of persons with inflammatory bowel disease (IBD) through the development of self-management strategies that address biological and socio-ecological factors. The costs of care and prevalence of IBD, a chronic gastrointestinal (GI) disease, have been rising in the United States. IBD symptoms (e.g., diarrhea, abdominal pain) negatively impact quality of life, work productivity, and school attendance; thus, there is a clear need to explore behavior modifications (e.g., behavior-influenced sleep-wake cycles) to mitigate the symptoms of those with IBD. Although animal models have shown the adverse effects of disrupted sleep-wake cycles on the GI system (e.g., intestinal dysbiosis), there is little research that focuses on the impact of inconsistent sleep-wake cycles on IBD health outcomes as well role of external socio-ecological factors (e.g., work and family obligations) on sleep-wake cycles of those with IBD. The aims of the proposed study that employ both quantitative and qualitative methods are to understand the relationship between rest- activity rhythm (RAR) characteristics and social jetlag with fatigue, sleep quality, GI symptoms, and disease activity, and identify the social and societal factors that impact sleep-wake cycles. Unlike most IBD sleep studies, this study will use objective actigraphy to measure RARs and social jetlag, and a qualitative portion will provide additional insight from IBD participants on socio-ecological factors that impact sleep-wake cycles which quantitative measures cannot fully capture. The socio-ecological model of health and sleep will guide the research project to consider the societal, social, and individual level impacts of sleep-wake cycles on IBD outcomes. The principal investigator will collect prospective data on 24 IBD participants from the University of Washington Medical Center's gastroenterology clinic and leverage existing data on 26 IBD participants from a previous study focused on nighttime sleep outcomes, resulting in a total of 50 participants. This award will prepare a pre-doctoral trainee through advanced coursework and direct research experience, qualitative and quantitative methods, focused analysis of RARs, and discovery of the relationships among three different concepts related to sleep-wake cycles and IBD-related health outcomes. The findings generated from this investigation will provide foundational knowledge for building a new program of research in self-management and symptom science in IBD.