Sleep-Wake Cycles of Individuals with Inflammatory Bowel Disease

炎症性肠病患者的睡眠-觉醒周期

• 批准号: 10604701
• 负责人: Linda Yoo
• 金额: $ 4.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-16 至 2025-09-15
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10604701
• 关键词: Abdominal Pain; Address; Adult; Adverse effects; American; Animal Model; Animals; Arousal; Award; Behavior; Behavior Therapy; Biologic Characteristic; Biological; Biological Markers; Characteristics; Chronic; Circadian Dysregulation; Circadian Rhythms; Clinic; Constipation; Crohn' s disease; Data; Development; Diarrhea; Disease; Disease Outcome; Disease remission; Electronics; Environment; Family; Fatigue; Fellowship; Financial Hardship; Functional disorder; Gases; Gastroenterology; Gastrointestinal Diseases; Genetic; Goals; Health; Healthcare; Hospitalization; Hour; Human; Individual; Individual National Research Service Award; Inflammatory; Inflammatory Bowel Diseases; Intervention; Interview; Intestines; Investigation; Jet Lag Syndrome; Knowledge; Lead; Leukocyte L1 Antigen Complex; Life; Life Style; Link; Measurement; Measures; Medical center; Metabolic; Methods; Minority; Modeling; Nausea; Nursing Research; Outcome; Participant; Patients; Persons; Pittsburgh Sleep Quality Index; Population; Prevalence; Principal Investigator; Productivity; Progressive Disease; Qualitative Methods; Quality of life; Questionnaires; Reporting; Research; Research Personnel; Research Project Grants; Research Training; Rest; Risk; Role; Sampling; Schedule; Schools; Self Management; Sleep; Sleep Disorders; Sleep Fragmentations; Sleep Wake Cycle; Sleep disturbances; Societal Factors; Structure; Symptoms; System; Testing; Time; Training; Ulcerative Colitis; United States; Universities; Washington; Work; Wrist; actigraphy; behavior influence; care costs; chronic autoimmune disease; circadian pacemaker; design; diaries; doctoral student; dysbiosis; experience; gastrointestinal symptom; gastrointestinal system; gut dysbiosis; improved; insight; intestinal barrier; lens; minority patient; mortality; pre-doctoral; programs; prospective; recruit; skills; sleep quality; social; social factors; social health determinants; stool sample; symptom science

PROJECT SUMMARY The purpose of this Ruth L. Kirschstein National Research Service Award (NRSA) Individual Pre-Doctoral Fellowship in Nursing Research (F31) application is to provide research training for Ms. Yoo, a beginning second-year doctoral student at the University of Washington (UW). The long-term goal of this training is for Ms. Yoo to develop into an independent researcher at a research-intensive academic setting with a program of research focused on improving health outcomes of persons with inflammatory bowel disease (IBD) through the development of self-management strategies that address biological and socio-ecological factors. The costs of care and prevalence of IBD, a chronic gastrointestinal (GI) disease, have been rising in the United States. IBD symptoms (e.g., diarrhea, abdominal pain) negatively impact quality of life, work productivity, and school attendance; thus, there is a clear need to explore behavior modifications (e.g., behavior-influenced sleep-wake cycles) to mitigate the symptoms of those with IBD. Although animal models have shown the adverse effects of disrupted sleep-wake cycles on the GI system (e.g., intestinal dysbiosis), there is little research that focuses on the impact of inconsistent sleep-wake cycles on IBD health outcomes as well role of external socio-ecological factors (e.g., work and family obligations) on sleep-wake cycles of those with IBD. The aims of the proposed study that employ both quantitative and qualitative methods are to understand the relationship between rest- activity rhythm (RAR) characteristics and social jetlag with fatigue, sleep quality, GI symptoms, and disease activity, and identify the social and societal factors that impact sleep-wake cycles. Unlike most IBD sleep studies, this study will use objective actigraphy to measure RARs and social jetlag, and a qualitative portion will provide additional insight from IBD participants on socio-ecological factors that impact sleep-wake cycles which quantitative measures cannot fully capture. The socio-ecological model of health and sleep will guide the research project to consider the societal, social, and individual level impacts of sleep-wake cycles on IBD outcomes. The principal investigator will collect prospective data on 24 IBD participants from the University of Washington Medical Center's gastroenterology clinic and leverage existing data on 26 IBD participants from a previous study focused on nighttime sleep outcomes, resulting in a total of 50 participants. This award will prepare a pre-doctoral trainee through advanced coursework and direct research experience, qualitative and quantitative methods, focused analysis of RARs, and discovery of the relationships among three different concepts related to sleep-wake cycles and IBD-related health outcomes. The findings generated from this investigation will provide foundational knowledge for building a new program of research in self-management and symptom science in IBD.

项目摘要 这个Ruth L的目的。Kirschstein国家研究服务奖（NRSA）个人博士预科 Fellowship in Nursing Research（F31）申请是为了给Yoo女士提供研究培训， 他是华盛顿大学（UW）二年级的博士生。本次培训的长期目标是 女士Yoo希望在研究密集型的学术环境中发展成为一名独立的研究人员， 研究的重点是通过改善炎症性肠病（IBD）患者的健康状况， 制定针对生物和社会生态因素的自我管理战略。的费用 IBD是一种慢性胃肠道（GI）疾病，在美国的治疗和患病率一直在上升。IBD 症状（例如，腹泻，腹痛）对生活质量，工作效率和学校产生负面影响 出席;因此，显然需要探索行为修改（例如，行为影响的睡眠-觉醒 周期），以减轻IBD患者的症状。尽管动物模型已经显示了 GI系统的睡眠-觉醒周期中断（例如，肠道生态失调），很少有研究关注 不一致的睡眠-觉醒周期对IBD健康结果的影响以及外部社会生态环境的作用 因素（例如，工作和家庭义务）对IBD患者的睡眠-觉醒周期的影响。建议的目标 采用定量和定性方法研究是为了了解休息- 活动节律（RAR）特征和社交时差与疲劳、睡眠质量、GI症状和疾病 活动，并确定影响睡眠-觉醒周期的社会因素。与大多数IBD睡眠不同 这项研究将使用客观的活动记录来测量RAR和社会时差，定性部分将 提供IBD参与者对影响睡眠-觉醒周期的社会生态因素的额外见解， 量化措施不能完全体现。健康和睡眠的社会生态模型将指导 一项研究项目，考虑睡眠-觉醒周期对IBD的社会，社会和个人水平的影响 结果。主要研究者将收集24名IBD受试者的前瞻性数据，这些受试者来自于 华盛顿医学中心的胃肠病学诊所，并利用现有的数据，26 IBD参与者，从一个 之前的研究主要关注夜间睡眠结果，共有50名参与者。这个奖项将 准备通过先进的课程和直接的研究经验，定性和 定量方法，对RAR的重点分析，以及三种不同的RAR之间的关系的发现， 与睡眠-觉醒周期和IBD相关健康结果相关的概念。由此产生的结果 调查将为建立一个新的自我管理研究计划提供基础知识 和症状学的研究。