How do small extracellular vesicles contribute to the development of prion disease

朊病毒疾病是与朊病毒蛋白质的错误折叠相关的可传播的神经退行性疾病。这项提案将研究细胞如何在称为外泌体的小纳米囊泡中释放导致朊病毒疾病的感染剂。我们将在exosomes中发现这两种神经退行性疾病所涉及的蛋白质的新加工形式，并研究exosomes的遗传内容是否具有诊断潜力。

Prion diseases are transmissible neurodegenerative disorders associated with the misfolding of the prion protein. This proposal will investigate how cells release the infectious agent responsible for prion diseases in small nanovesicles known as exosomes. We will characterise the novel processed forms of the proteins involved in these two neurodegenerative diseases within the exosomes and investigate whether the genetic content of exosomes has diagnostic potential.