How do small extracellular vesicles contribute to the development of prion disease

小细胞外囊泡如何促进朊病毒病的发展

• 批准号: nhmrc : GNT1041413
• 负责人: A/Pr Victoria Lawson
• 金额: $ 56.39万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/small-extracellular-vesicles-prion-disease/1344378
• 关键词: How; do; small; extracellular; vesicles

Prion diseases are transmissible neurodegenerative disorders associated with the misfolding of the prion protein. This proposal will investigate how cells release the infectious agent responsible for prion diseases in small nanovesicles known as exosomes. We will characterise the novel processed forms of the proteins involved in these two neurodegenerative diseases within the exosomes and investigate whether the genetic content of exosomes has diagnostic potential.

朊病毒疾病是与朊病毒蛋白错误折叠相关的传染性神经退行性疾病。这项提议将研究细胞如何在被称为外泌体的小纳米囊泡中释放负责朊病毒疾病的感染因子。我们将描述外泌体中涉及这两种神经退行性疾病的蛋白质的新加工形式，并研究外泌体的遗传内容是否具有诊断潜力。