Statistical analyses of whole genome genotype data to better understand psychiatric disorders

到目前为止，确定疾病之间重叠的遗传病因，需要大量的家族记录研究队列。在这里，我们将使用独立病例对照样本的全基因组基因型直接从分子数据中估计共同的遗传病因。通过这种方式，我们将探索以前难以解决的问题，如类风湿性关节炎与精神分裂症的关系，这是一个公认的流行病学难题。

Until now, determining an overlapping genetic aetiology between disorders, required large study cohorts of family records. Here we will use genome-wide genotypes available on independent case-control samples to estimate a shared genetic aetiology directly from the molecular data. In this way we will explore previously intractable questions, such as the relationship between rheumatoid arthritis in people with schizophrenia, a well-recognised epidemiological puzzle.