Functional interactions between shox and hox genes during limb development

shox 和 hox 基因在肢体发育过程中的功能相互作用

• 批准号: 355731-2008
• 负责人: Cobb, John
• 金额: $ 2.84万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=402674
• 关键词: Functional; interactions; between; shox; hox

Transcription factor proteins control gene expression during development in order to introduce pattern into the embryo. One such patterning process is the formation of the limbs (arms and legs) in the embryo. We now know that different transcription factors are necessary to develop specific segments of the limbs. For this reason, birth defects can result when the function of a transcription factor is missing. Because developmental pattering is similar in all mammals, we use limb development in the mouse as a model. For example, we have found that the mouse transcription factor Shox2 is necessary to form the proximal segment of the limbs (the humerus in the arms and the femur in the legs). Shox2 is closely related to the human SHOX protein, which is necessary for normal limb development in humans.

转录因子蛋白在发育过程中控制基因表达，以便将模式引入胚胎。 一个这样的模式化过程是胚胎中四肢（手臂和腿）的形成。 我们现在知道，不同的转录因子是必要的，以发展特定节段的肢体。 因此，当转录因子的功能缺失时，可能会导致出生缺陷。 由于所有哺乳动物的发育模式都是相似的，我们使用小鼠的肢体发育作为模型。 例如，我们发现小鼠转录因子Shox 2是形成肢体近端部分（臂中的肱骨和腿中的股骨）所必需的。 Shox2与人类SHOX蛋白密切相关，这是人类正常肢体发育所必需的。