The role of RanGTP in the spatial organization of mitotic cells

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For organisms to grow and develop they must continually increase the numbers of cells within them. To achieve this cells can divide into two. For the two resultant cells to survive they must have a complete complement of the organisms genetic material, otherwise they will die or become misregulated. Therefore cell division must only occur once the genetic material has duplicated and separated, otherwise there would be an unequal distribution of the genetic material between the 2 newly forming cells. We have evidence to suggest that the chromosomes in each cells contribute to spatially organizing a cell so that it will only divide to produce two cells with an equal genetic content. We porpose to determine how the chromosomes regulate the process of cell division.