The role of RanGTP in the spatial organization of mitotic cells

RanGTP 在有丝分裂细胞空间组织中的作用

• 批准号: 356045-2008
• 负责人: Wilde, Andrew
• 金额: $ 2.55万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=431914
• 关键词: role; RanGTP; spatial; organization; mitotic

For organisms to grow and develop they must continually increase the numbers of cells within them. To achieve this cells can divide into two. For the two resultant cells to survive they must have a complete complement of the organisms genetic material, otherwise they will die or become misregulated. Therefore cell division must only occur once the genetic material has duplicated and separated, otherwise there would be an unequal distribution of the genetic material between the 2 newly forming cells. We have evidence to suggest that the chromosomes in each cells contribute to spatially organizing a cell so that it will only divide to produce two cells with an equal genetic content. We porpose to determine how the chromosomes regulate the process of cell division.

生物体要生长发育，就必须不断增加体内细胞的数量。为了达到这个目的，细胞可以分裂成两个。为了使两个合成的细胞存活，它们必须具有生物体遗传物质的完整补充，否则它们将死亡或变得失调。因此，细胞分裂必须在遗传物质复制和分离后才会发生，否则遗传物质在两个新形成的细胞之间的分布就会不均匀。我们有证据表明，每个细胞中的染色体有助于细胞的空间组织，因此它只会分裂产生两个具有相同遗传含量的细胞。我们的目的是确定染色体如何调节细胞分裂的过程。