Stem cell treatment for tendon degeneration

肌腱退化的干细胞治疗

• 批准号: nhmrc : 570922
• 负责人: Dr James Melrose
• 金额: $ 45.69万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stem-cell-treatment-tendon-degeneration/97074
• 关键词: Stem; cell; treatment; tendon; degeneration

Degeneration and tearing of tendons such as the rotator cuff is a major health issue in working and ageing Australians. Tendon ruptures are preceded by degenerartive change which contributes to the poor success with surgical repair. There are very limited medical treatments available. We have developed an animal model mimicing human tendon dgeneration and will determine the utility and mechanisms of action of using a novel new therapy, stem cells in modulating degenerarion and aiding repair.

肌腱退化和撕裂，如肩袖，是澳大利亚上班族和老年人的一个主要健康问题。肌腱断裂之前会发生退行性改变，这导致手术修复的成功率较低。可用的医疗手段非常有限。我们已经开发了一个模拟人类肌腱退化的动物模型，并将确定使用一种新的治疗方法的效用和作用机制，干细胞在调节退化和帮助修复中。