Mesenchymal Progenitor cells and intervertebral disc repair

间充质祖细胞与椎间盘修复

• 批准号: nhmrc : 1004032
• 负责人: Dr James Melrose
• 金额: $ 50.29万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mesenchymal-progenitor-cells-disc-repair/108992
• 关键词: Mesenchymal; Progenitor; cells; intervertebral; disc

Low back pain affects 80% of the general population and is a major social and economic burden thus there is a clear need for effective treatment. Annual direct and indirect costs for low back pain exceeded $100 billion in the USA in 2006. We will use bone marrow derived multipotent progenitor cells in a regenerative strategy to undertake repair of the intervertebral disc in an ovine mechanical destabilisation model which reproduces early degenerative changes similar to those evident in man.

腰痛影响了80%的总人口，是一种主要的社会和经济负担，因此显然需要有效的治疗。2006年，美国腰痛的年直接和间接成本超过1000亿美元。我们将在再生策略中使用骨髓来源的多能祖细胞来修复绵羊机械失稳模型中的椎间盘，该模型再现了与人类明显相似的早期退行性变化。