Development and validation of a fathead minnow liver cell line for environmental testing

用于环境测试的黑头鲦鱼肝细胞系的开发和验证

• 批准号: 356651-2007
• 负责人: Law, David
• 金额: $ 6.52万
• 依托单位: Lakehead University
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects Supplemental Competition
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=403040
• 关键词: Development; validation; fathead; minnow; liver

Primary industries such as forestry, pulp and paper manufacturing and municipal waste treatment facilities employ significant numbers of Canadians. Their operations use large amounts of water and when they return it to the environment it may contain chemicals that affect the ability of animals to successfully reproduce. The fathead minnow is a model species used in experiments to predict the health of other animals in waterways. Industry and government regulatory agencies use live minnows to screen aquatic effluents for toxicity. However, these tests are expensive and cumbersome. The primary organ in vertebrates involved in detoxification of environmental contaminants is the liver, and it is very sensitive to low levels of these

林业、纸浆和造纸等初级产业以及城市废物处理设施雇用了大量加拿大人。他们的操作使用大量的水，当他们将水排放到环境中时，水可能含有影响动物成功繁殖能力的化学物质。在实验中，大头鲦鱼是一种模型物种，用来预测水道中其他动物的健康状况。工业和政府管理机构使用活鲦鱼来筛选水生废水的毒性。然而，这些测试既昂贵又繁琐。参与环境污染物解毒的脊椎动物的主要器官是肝脏，它对这些污染物的低水平非常敏感